2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glutathione Reductase (GR)

Glutathione Reductase (GR)

Glutathione Reductase

Glutathione reductase (GR) is a flavoenzyme whose main function is to catalyze the reduction of oxidized glutathione (GSSG) to reduced glutathione (GSH), playing a crucial role in the redox balance of cells. Glutathione reductase maintains the dynamic equilibrium between the two forms of glutathione within the cell, indirectly participates in antioxidant processes such as the elimination of reactive oxygen species in the cell, and protects cells from oxidative damage. In addition, it is also involved in the detoxification processes of organs such as the liver. Abnormal activity of glutathione reductase can lead to cellular redox imbalance and plays an important role in the occurrence and development of cardiovascular diseases, neurodegenerative diseases, hemolytic anemia, liver diseases, etc[1].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1820
    Zinc sulphate
    		Inhibitor 99.85%
    Zinc sulphate is an orally active inhibitor of tyrosinase and glutathione reductase. Zinc sulphate enhances the activity of dopachrome tautomerase. Zinc sulphate delays anagen-related eumelanin production, induces hair hypopigmentation in mice, and accelerates wound healing. Zinc sulphate can be used in research related to benign gastric ulcers. Zinc sulphate can be used in research related to rheumatoid arthritis.
    Zinc sulphate
  • HY-N0910
    Notoginsenoside Ft1
    		Activator 99.49%
    Notoginsenoside Ft1 is an orally active bioactive saponin. Notoginsenoside Ft1 inhibits the PI3K/AKT/mTOR signaling pathway, activates the p38 MAPK and ERK1/2 signaling pathways, and increases the proportion of CD8+ T cells, thereby inducing apoptosis and lysosomal cell death in various cancer cells, and promoting angiogenesis. Notoginsenoside Ft1 causes vasodilation by activating glucocorticoid receptors (GR) and estrogen receptor beta (ERβ) in endothelial cells. Notoginsenoside Ft1 increases intracellular Ca2+ accumulation, reduces cAMP levels by activating a signaling network mediated through P2Y12 receptors, and promotes platelet aggregation, thereby exerting a procoagulant effect. Notoginsenoside Ft1 inhibits ferroptosis (ferroptosis) in renal tubular epithelial cells by activating the TGR5 receptor, thereby demonstrating a renal protective effect. Notoginsenoside Ft1 acts as a TGR5 agonist and an FXR antagonist to combat obesity and insulin resistance.
    Notoginsenoside Ft1
  • HY-12542S
    Dantrolene-13C3
    		Inhibitor 99.0%
    Dantrolene-13C3 is the 13C3 labeled Dantrolene. Dantrolene (F368), a muscle relaxant, non-competitively inhibits human erythrocyte glutathione reductase. Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca2+ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.
    Dantrolene-<sup>13</sup>C<sub>3</sub>
  • HY-Y0590
    Copper(I) oxide
    		Inhibitor
    Copper (I) oxide is an oxidative stress inducer and cytotoxic agent. Copper (I) oxide causes dose-dependent decrease in the viability of airway epithelial cells by impairing the activities of catalase and glutathione reductase, generating reactive oxygen species, and increasing the levels of 8-isoprostane and the ratio of oxidized glutathione. However, when combined with Resveratrol (HY-16561), the cytotoxic effect induced by Copper (I) oxide is significantly attenuated, and oxidative damage is effectively alleviated.
    Copper(I) oxide
  • HY-125862B
    Glutathione Reductase, Spinach
    Glutathione Reductase,Wheat germ (EC 1.6.4.2) is a crucial flavoenzyme in the antioxidant defense system. Reduced glutathione (GSH) is used by glutathione peroxidase to detoxify hydrogen peroxide and in the precess is converted to oxidized glutathione (GSSG). The GSSG is then recycled back to GSH by glutathione reductase (GR) using NADPH that is then converted to NADP+. The regenerated GSH is then available to detoxify more hydrogen peroxide. Glutathione Reductase uses FAD as a cofactor.
    Glutathione Reductase, Spinach
  • HY-125862A
    Glutathione Reductase,Wheat germ
    Glutathione Reductase,Wheat germ (EC 1.6.4.2) is a crucial flavoenzyme in the antioxidant defense system. Reduced glutathione (GSH) is used by glutathione peroxidase to detoxify hydrogen peroxide and in the precess is converted to oxidized glutathione (GSSG). The GSSG is then recycled back to GSH by glutathione reductase (GR) using NADPH that is then converted to NADP+. The regenerated GSH is then available to detoxify more hydrogen peroxide. Glutathione Reductase uses FAD as a cofactor.
    Glutathione Reductase,Wheat germ
Cat. No. Product Name / Synonyms Application Reactivity